| Autor: |
Soumyasanta Laha, Vishawajeet Puri, Nikhil J. Dhinagar, Yunus Kelestemur, Savas Kaya |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
BioCAS |
| DOI: |
10.1109/biocas.2018.8584693 |
| Popis: |
A working prototype of a wearable continuous noninvasive glucose monitoring system based on near infra-red (NIR) illumination at 940nm has been implemented and demonstrated with a phase-sensitive analog detector front-end and digital backend. The proposed design is capable of tracking the naturally weak NIR interactions in both transmissive (absorbance) and reflective (diffused reflectance) mode, depending on the optical head design. The front-end of the high-fidelity lock-in detection system is implemented using purely analog components consisting of a pre-amplifier integrated with the photo-sensor and an analog single-chip CMOS lock-in-amplifier, which enhances signal-to-noise ratio (SNR), thus reducing the need for an aggressive signal processing (i.e. power consumption) in the digital backend. Following the discrete measurements using transmissive NIR illumination that confirmed the viability of the proposed analog front-end design, continuous measurements of both transmissive absorbance and diffused NIR reflectance were recorded. Oral glucose tolerance tests (OGTT) have been performed on fasting human subjects by the intake of 50 gm glucose solution or tablets. Concurrent measurements of the proposed non-invasive techniques and conventional invasive blood pricking were executed to provide a control for comparison. The temporal trend observed on the same OGTT protocol from the proposed continuous compact glucometer and control measurements strongly correlates, validating the clinical significance of the proposed prototype. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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