Adsorption of zwitterionic drugs on oxidized cellulose from aqueous solutions
| Autor: | T. L. Yurkshtovich, Dmitry S. Zimnitsky, Pavel M. Bychkovsky |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Sorbent
Aqueous solution Polymers and Plastics Ion exchange General Chemical Engineering Oxidized cellulose Inorganic chemistry Langmuir adsorption model General Chemistry Biochemistry chemistry.chemical_compound symbols.namesake Adsorption chemistry Zwitterion Materials Chemistry symbols Environmental Chemistry Organic chemistry Carboxylate |
| Zdroj: | Reactive and Functional Polymers. 66:519-525 |
| ISSN: | 1381-5148 |
| DOI: | 10.1016/j.reactfunctpolym.2005.10.004 |
| Popis: | Adsorption of zwitterionic drugs (β-lactam antibiotics and amino acids) on samples of oxidized cellulose (OC) with various carboxyl contents and structure characteristics from aqueous solutions was investigated. It was established, that drug binding with OC occurs via proton transfer from carboxyl group of ion exchanger to the carboxylate ion of adsorbed zwitterion. The adsorption process can be described according to the theory of localized stoichiometric adsorption and represented by Langmuir-like isotherms. The constants of sorbate interfacial distribution with some exceptions increase with a growth of sorbate relative hydrophobicity. The drug uptake is shown to increase with an increase of carboxyl content in the OC phase. The degree of crystallinity of sorbent has no considerable effect on drug adsorption from aqueous solutions. |
| Databáze: | OpenAIRE |
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