VITAMIN D NANOCAPSULATION
| Autor: | Taisiya S. Gutnova, A. V. Blinov, A. A. Gvozdenko, Dmitry V. Kompantsev, Vasily N. Kramarenko |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA. 64:98-105 |
| ISSN: | 2500-3070 0579-2991 |
| Popis: | The main objective of the planned experiment is to obtain a stabilized nanoemulsion of vitamin D3, followed by obtaining nanocapsules of vitamin D3 with a high biological potential, as well as to analyze the spatial (dimensional) characteristics, to study the stability and stability of the resulting product. In the presented study, the physicochemical and technological properties of the vitamin D substance were studied and the optimal ultradispersion mode was selected. The composition is experimentally established and a technology for obtaining laboratory samples of nanocapsules is proposed. The shape and size of the obtained nanocapsules with vitamin D were studied. Based on the developed experimental model, the optimal composition of nanocapsules was obtained. The quantitative content of vitamin D3 in the analyzed sample of nanocapsules was 76.9% with a holding time of 2.0 min. The results of studying the stability and stability of vitamin D nanocapsules proved their stability for 12 months. The developed vitamin D nanocapsules are a way of modifying the vitamin D substance for the subsequent production of tablets with improved biopharmaceutical properties. The selection of the composition of excipients based on the prediction of their properties, as well as the technology for producing nanocapsules, allows to increase the duration of the therapeutic effect while simultaneously reducing the maximum concentration of the drug in the body. The optimal composition of solubilizers for achieving a more complete, rapid and targeted dissolution of the active substance in a given part of the intestine has been experimentally confirmed. The aim of the study is to obtain a quality drug with improved properties such as adequate bioavailability, safety, low toxicity, no side effects and controlled release. |
| Databáze: | OpenAIRE |
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