Regulation der PEP-Carboxylase des fakultativ methylotrophenAcetobacter sp.MB 58

Autor:	Wolfgang Babel, N. Loffhagen
Rok vydání:	1982
Předmět:	De novo synthesis Biochemistry Anabolism Effector Catabolism Genetics Glycolysis Oxidative phosphorylation Energy charge Biology Applied Microbiology and Biotechnology Pyruvate kinase
Zdroj:	Zeitschrift für allgemeine Mikrobiologie. 22:453-463
ISSN:	0044-2208
Popis:	Acetobacter sp. MB 58 assimilates methanol via the fructose-1,6-bisphosphate variant of the hexulose phosphate pathway. Glyceraldehyde-3-phosphate originates as net product of an assimilation loop involving the regeneration of the C1-acceptor ribulose-5-phosphate and must be available for the de novo synthesis of the C1-acceptor as well as for the oxidative glycolysis. It is made probable in a regulatory model that this is accomplished via alternating anabolic and catabolic phases which are controlled by concerted action of PEP-carboxylase and pyruvate kinase. Whereas Ac-CoA is a crucial effector and a-ketoglutarate and aspartate are inhibitors for the PEP-carboxylase, the pyruvate kinase is assumed to be regulated by energy charge.
Databáze:	OpenAIRE
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