Effect of Intravenous Immunoglobulin in Reducing Bilirubin Levels in Hemolytic Disease of Newborn
| Autor: | Marwa M Elgendy, Aisha Abd-Ellatif Elsaied Ahmed, Mohammed Abd-Ellatif Nassar, Hamed Mohammed El-Sharkawy, Shaimaa Waheed Ibrahim El Fekey |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
business.industry Bilirubin medicine.medical_treatment Exchange transfusion Jaundice medicine.disease Group A Group B 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030225 pediatrics ABO blood group system Anesthesia Hemolytic disease of the newborn (ABO) medicine biology.protein 030212 general & internal medicine medicine.symptom Antibody business |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 74:957-968 |
| ISSN: | 2090-7125 |
| DOI: | 10.21608/ejhm.2019.25779 |
| Popis: | Background: hemolytic disease of the newborn is an autoimmune haemolytic disease and caused by antibodies produced due to Rh and ABO incompatibilities. Neonatal jaundice is a common clinical problem encountered during the neonatal period. To avoid the associated neurological complications; exchange transfusion and phototherapy have been traditionally used. Aim of the work: was to assess the efficacy of intravenous immunoglobulins in neonates with Rh and/or ABO incompatibility in reducing the duration of phototherapy and the need for exchange transfusion and hospital stay. Subjects and Methods: in this clinical intervention study 40 patients diagnosed with hemolytic disease of newborn were grouped into group A and B. All neonates were treated with standard protocol for phototherapy and exchange transfusion. Group A patients received only phototherapy. Group B patients received intravenous immunoglobulins in a dose of 0.5 gm/kg of body weight single dose and phototherapy. Exchange transfusion was given to the patients of both groups if the bilirubin rose by 0.5 mg/dl per hour. Results: there was a significant decrease of bilirubin level in group B [that received phototherapy plus Intravenous Immunoglobulin (IVIG)] than group A [that received phototherapy only]. Hospital stay and duration of phototherapy decreased in group B than group A. Number of cases exchanged blood in group A was higher than cases of group B. Conclusion: addition of intravenous immunoglobulins for treatment of hemolytic disease of newborn significantly reduces bilirubin levels, duration of phototherapy, need for exchange transfusion and hospital stay. |
| Databáze: | OpenAIRE |
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