Intracisternally localized lupus serum IgG induces meningitis (HUM3P.245)
| Autor: | Guo-Min Deng, Lingyun Sun, Xiang Liao, Chang-hao Xie |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 194:121.5-121.5 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.194.supp.121.5 |
| Popis: | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by high autoantibody levels and multiorgan tissue damage, including brain. Headache in SLE patients is frequent clinical manifestations and its etiology and pathogenesis remains unclear. We hypothesized that lupus serum containing high levels of IgG induces meningitis. Information from the analyzed 150 lupus patients demonstrates higher levels of IgG in CSF from lupus patients with headache than that without headache. There is meningitis in brain of MRL/lpr mice. We have intracisternally injected mice and rats with serum from patients with SLE, health individuals, lupus prone mice and normal mice , and found meningitis induced only by serum from lupus patients and lupus prone mice. Meningitis induced by lupus serum appeared 12 h and peaked 3 days after injection. Deleted the monocyte/ macrophage abrogated meningitis but lack of lymphocyte did not affect the development of meningitis induced by lupus serum. Specific interactions with vascular selectin expression and depletion of complement system led to a significant amelioration of meningitis. Depletion of IgG from lupus serum reduced meningitis suggests that IgG is important contributor in lupus serum-induced meningitis. Intracisternally lupus serum may trigger development of hippocampus neuron apoptosis. This study proves that lupus serum IgG induces meningitis, which is important mechanism of headache of lupus patients. |
| Databáze: | OpenAIRE |
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