AB0974 Association between diabetes mellitus as part of metabolic syndrome and osteoarthritis (preliminary data)
| Autor: | L. Alekseeva, E. Taskina, N. Kashevarova, D. Kusevich, K. Telyshev, E. Strebkova, E. Sharapova, D. Kudinsky, O. Alekseeva, N. Demin, O. Tenkova, E. Kharlamova, A. Abolyoshina |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of the Rheumatic Diseases. 81:1613.2-1614 |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | BackgroundThere are more evidence that diabetes mellitus (DM) aggravates the course of osteoarthritis (OA).ObjectivesAt multicenter study to evaluate impact of DM as part of metabolic syndrome on course of knee OA.MethodsThe enrolled patients had knee OA based on ACR criteria with x-ray confirmation with stage I-III (Kellgren and Lawrence (K&L). Mean disease duration was 5 (2-10) years. Patients were evaluated by report form, using the anthropometric parameters, questionnaires, disease history and comorbidity, clinical examination data, assessment of knee joints pain, standard X-ray, ultrasound signs of OA, DXA three sites the L1-L4 lumbar spine, femoral neck, and total hip. All participants were signed an informed consent form.ResultsAt prospective study were enrolled 253 women with mean age 58.3 ± 9.5 years (40-75) years, with knee OA. Compensated DM type 2 was diagnosed in 26 (10.3%) patients with knee OA. All patients with knee OA were divided into two groups:1st group was with DM and 2nd group without DM (Table 1). Patients with DM were older, had higher weight and BMI. In patients with DM was harder course of OA based on clinical and instrumental data: higher pain by WOMAC score; at X-ray were more frequent confirmed III stage (K&L) (ОR=3.1, 95%CI 1.1-8.7, р= 0.01). At X-ray investigation narrow of medial joint space and at ultrasound thickness of the cartilage were also smaller at 1st group (рTable 1.Comparative characteristics of patients with OA with or without DM.Parameters1 group (n=26)2 group (n=227)pAge, years, Me65.5 (60- 68)59 (52- 65)0.002BMI, кg/m2, Me33.5 (29.4- 35.8)28.7 (25.6- 32.3)0.0006OA duration, years, Ме11 (7- 18)4 (2-10)0.0032Generalized ОА, %5024.50.009WOMAC pain, mm, Ме199 (158- 230)120 (45- 190)0.005X-ray stage (K&L), %I8.732.50.04II65.257.3III26.110.2Medial knee joint space, mm, Ме2 (0.6- 3.1)3.4 (2.2- 4.5)0.03Cartilage thickness in posterior-lateralis area of knee joint, mm, Ме1.5 (1.4-1.7)1.7 (1.6- 1.9)0.05HbA1c, %; Ме7.2 (5.4-7.7)5.4 (5-5.7)0.01Glucosae, mmol/l, Ме6.6 (5.1-6,9)5.3 (4.9- 5.7)0.003Hypertension, %84.660.80.01Metabolic syndrome, %92.354.20.0002Medial knee joint space, mm, Ме2 (0.6- 3.1)3.4 (2.2- 4.5)0.03Cartilage thickness in posterior-lateralis area of knee joint, mm, Ме1.5 (1.4-1.7)1.7 (1.6- 1.9)0.05BMD total hip, g/cm2, Ме0.966 (0.955-1.054)0.878 (0.801-0.944)0,04Number of components of MS, %0021.10.0009I10.532.8II47.436.7III and more41.29.4Nonalcoholic steatohepatitis, %18.80.80.003In the Spearman correlation analysis are confirmed positive associations between DM and more difficult and prolonged course of OA. We found out that higher WOMAC pain subscale (r=0.18), total hip BMD at DXA (r=0.25), smaller size of medial joint space (r=-0.24) and thickness of the cartilage at ultrasound (r= -0.13) are associated with DM (рConclusionThe patients with OA are high frequent comorbidity with DM (10.3%). Association OA and DM lead to severe OA and higher comorbidity.ReferencesNoneDisclosure of InterestsNone declared |
| Databáze: | OpenAIRE |
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