ChemInform Abstract: Highly Efficient Deacetylation by Use of the Neutral Organotin Catalyst [tBu2SnOH(Cl)]2

Autor:	Shinji Toyoshima, Yuuki Hamada, Junzo Otera, Takehiko Nakano, Akihiro Orita
Rok vydání:	2010
Předmět:	Primary (chemistry) Acetylation Chemistry Organic chemistry General Medicine Tertiary alcohols Racemization Catalysis
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200212092
Popis:	Deprotection of acetyl esters is effected cleanly by the neutral organotin catalyst, [tBu2SnOH(Cl)]2. The mildness of the reaction gives rise to great synthetic versatility and in the process a variety of functional groups are tolerated. Differentiations between primary, secondary, and tertiary alcohols and between acetyl ester and other esters are feasible. No racemization occurs with chiral acetyl esters. Exclusive deprotection of primary acetyl esters in carbohydrates and nucleosides is observed. The crude product thus obtained can be used for further reactions without purification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dbbd18a6837f90bdde43d446ac537768 https://doi.org/10.1002/chin.200212092 Zobrazit plný text záznamu Plný text