Male Mammary Paget Disease: A Tale of 2 Contrasting Cases
| Autor: | Madhuchhanda Roy, Mediget Teshome, Aysegul Sahin, Rosalind P. Candelaria, Senthil Damodaran, Constance Albarracin, Deanna L. Lane, Victor G. Prieto, Elsa Arribas, Laila Khazai, Priyadharsini Nagarajan, Marion E. Scoggins, Sharon H. Giordano |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Dermatology General Medicine Disease Ductal carcinoma Rash Pathology and Forensic Medicine Lesion 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Paget Disease Biopsy medicine Itching medicine.symptom skin and connective tissue diseases business Areola |
| Zdroj: | The American Journal of Dermatopathology. 42:981-985 |
| ISSN: | 0193-1091 |
| Popis: | Mammary Paget disease (MPD) comprises 1.45% all male breast cancers, compared with only 0.68% of all female breast cancers. Patients usually present in the fifth and sixth decades of life with ulceration, eczematous changes, discharge, bleeding, itching, and induration of the nipple and areola. Typically, there is a delay in definitive diagnosis and treatment from the onset of symptoms because most patients are initially treated for a rash. At the time of diagnosis, about half of the patients may have palpable breast mass, positive lymph nodes, or both. In this article, we present 2 cases of male MPD representing the extremes of clinical, radiologic, and histopathologic spectrum of the disease. One patient presented with a rash of the nipple of several months duration without an underlying lesion, whereas the other presented with sensitivity and pain of the nipple for 1 year and an underlying mass. Biopsies were diagnostic of MPD in both cases, and definitive surgery revealed an underlying ductal carcinoma in situ in the first case and an invasive ductal carcinoma in the second, highlighting the importance of early biopsy to initiate appropriate management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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