Effect of Caloric Restriction on Metabolism of Polycyclic Aromatic Hydrocarbons by Male B6C3F1Mouse Liver Microsomes

Autor:	Ming W. Chou, Linda S. Von Tungeln, Ronald W. Hart, Peter P. Fu, De-Jin Zhan, Ying Xiao
Rok vydání:	1994
Předmět:	Anthracene Metabolizing enzymes Polymers and Plastics Cytochrome biology Organic Chemistry Regioselectivity Metabolism medicine.disease_cause chemistry.chemical_compound chemistry Biochemistry Materials Chemistry biology.protein medicine Stereoselectivity Carcinogenesis Liver microsomes
Zdroj:	Polycyclic Aromatic Compounds. 7:19-26
ISSN:	1563-5333 1040-6638
DOI:	10.1080/10406639408014708
Popis:	Effect of caloric restriction (CR) on metabolism of 7-fluorobenz-[a]anthracene (7-F-BA), 7-chlorobenz[a]anthracene (7-Cl-BA), 7-bromo-benz[a]anthracene (7-Br-BA), and 7-nitrobenz[a]anthracene (7-nitro-BA) by mouse liver microsomes was studied. The results indicate that CR can affect metabolism rate, modulate the regioselectivity and stereoselectivity of the cytochrome P-450 metabolizing enzymes, and lower the yield of the proximate mutagenic metabolites. These findings indicate that CR may in part modulate chemical carcinogenesis by altering the metabolic activation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dbb264d68f734d748fd915d2e6f41001 https://doi.org/10.1080/10406639408014708 Zobrazit plný text záznamu