Synthesis and NMR Characterization of Multi‐hydroxyl End‐groups PEG and PLGA‐PEG Barbell‐like Copolymers

Autor:	Jian‐Chao Yuan, Zi-Qiang Lei, Long‐Gang You, De‐Dai Lu
Rok vydání:	2008
Předmět:	Telechelic polymer Materials science Polymers and Plastics technology industry and agriculture macromolecular substances General Chemistry Biodegradable polymer chemistry.chemical_compound End-group PLGA Monomer chemistry Polymer chemistry PEG ratio Materials Chemistry Ceramics and Composites Ethylene glycol Glycolic acid
Zdroj:	Journal of Macromolecular Science, Part A. 45:705-711
ISSN:	1520-5738 1060-1325
Popis:	Multi‐hydroxyl end‐groups poly(ethylene glycol) (PEG) was prepared from PEG and epichlorohydrin. Then, PEG‐supported poly(lactic‐ran‐glycolic acid) (PLGA)n‐PEG‐(PLGA)n (n=1, 2, 4) linear‐dendritic barbell‐like copolymers were synthesized through direct polycondensation under bulk condition from the multi‐hydroxyl end‐groups PEG, lactic acid and glycolic acid. Arm numbers were varied, with 2, 4 and 8, by using bis‐, tetra‐, and octa‐hydroxyl end‐groups PEG, respectively. The chemical structures, absolute number‐average molecular weight, the monomer units per single arm and the molar ratio of hydroxyl acid monomer units of the (PLGA)n‐PEG‐(PLGA)n barbell‐like copolymers were analyzed by NMR spectroscopy. The result indicated that the structures of the multi‐hydroxyl end‐groups PEG and (PLGA)n‐PEG‐(PLGA)n barbell‐like copolymers were consistent with design. Compared with the theoretical values, molecular weights determined by 1H‐NMR end‐group analysis gave reasonably consistent values, but the values determi...
Databáze:	OpenAIRE
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