HLA-DRB1*1501 influences long-term disability progression and tissue damage on MRI in relapse-onset multiple sclerosis
| Autor: | Wallace J Brownlee, Carmen Tur, Andreea Manole, Arman Eshaghi, Ferran Prados, Katherine A Miszkiel, Claudia AM Gandini Wheeler-Kingshott, Henry Houlden, Olga Ciccarelli |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Multiple Sclerosis Journal. 29:333-342 |
| ISSN: | 1477-0970 1352-4585 |
| Popis: | Background: Whether genetic factors influence the long-term course of multiple sclerosis (MS) is unresolved. Objective: To determine the influence of HLA-DRB1*1501 on long-term disease course in a homogeneous cohort of clinically isolated syndrome (CIS) patients. Methods: One hundred seven patients underwent clinical and MRI assessment at the time of CIS and after 1, 3, 5 and 15 years. HLA-DRB1*1501 status was determined using Sanger sequencing and tagging of the rs3135388 polymorphism. Linear/Poisson mixed-effects models were used to investigate rates of change in EDSS and MRI measures based on HLA-DRB1*1501 status. Results: HLA-DRB1*1501 -positive ( n = 52) patients showed a faster rate of disability worsening compared with the HLA-DRB1*1501 -negative ( n = 55) patients (annualised change in EDSS 0.14/year vs. 0.08/year, p 2/year, p Interpretation: These findings provide evidence that the HLA-DRB1*1501 allele plays a role in MS severity, as measured by long-term disability worsening and a greater extent of inflammatory disease activity and tissue loss. HLA-DRB1*1501 may provide useful information when considering prognosis and treatment decisions in early relapse-onset MS. |
| Databáze: | OpenAIRE |
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