| Autor: |
Xi-Jian Liu, Keyun Sun, Tao Han, G.-X. Zu, Q.-Q. Sun, Jian Chen, Liang-Kun Zhang, Ling Li, Hailiang Huang, Guoxiu Zu |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.1101/2020.07.02.184218 |
| Popis: |
Background/Aim: To use liquid chromatography-mass spectrometry (LC-MS) to identify endogenous differential metabolites in the urine of rats with chronic atrophic gastritis (CAG). Materials and Methods: Methylnitronitrosoguanidine (MNNG) was used to produce a CAG model in Wistar rats, and HE staining was used to determine the pathological model. LC-MS was used to detect the differential metabolic profiles in rat urine. Diversified analysis was performed by the statistical method. Results: Compared with the control group, the model group had 68 differential metabolites, 25 that were upregulated and 43 that were downregulated. The main metabolic pathways were D-glutamine and D-glutamic acid metabolism, histidine metabolism and purine metabolism. Conclusion: By searching for differential metabolites and metabolic pathways in the urine of CAG rats, this study provides effective experimental data for the pathogenesis and clinical diagnosis of CAG. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
