Lewis Blood Group Antigens are Associated with Altered Susceptibility to Shigellosis

Autor:	William A. Petri, Uma Nayak, Erin Weddle, Jhansi L. Leslie, Beth D. Kirkpatrick, Rashidul Haque, Hervé Agaisse, Ye Lin, James A Platts-Mills, Benjamin Lee, Jennie Z. Ma, Lauren K. Yum, Matthew L. Jenior
Rok vydání:	2020
Předmět:	Glycan Shigellosis biology business.industry biology.organism_classification medicine.disease In vitro Blood group antigens Shigella flexneri Antigen Cohort Immunology biology.protein Medicine business Fucosylation
DOI:	10.1101/2020.09.09.20191478
Popis:	In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db9bbdcc4182615c396fed74694ec976 https://doi.org/10.1101/2020.09.09.20191478 Zobrazit plný text záznamu