Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces β3-adrenoceptor-mediated relaxation, causing rat detrusor overactivity
| Autor: | Fernando Maurício Francis Abdalla, Angelina Zanesco, Fabíola Z. Mónica, Marcelo Nicolas Muscará, A A O Bricola, Edson Antunes, Fernando R. Báu, L L Lopes Freitas, Catarina S. Porto, Simone A. Teixeira, G. De Nucci |
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| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
Detrusor muscle medicine.medical_specialty Urinary bladder Chemistry medicine.disease Nitric oxide B vitamins chemistry.chemical_compound Endocrinology medicine.anatomical_structure Overactive bladder Internal medicine Muscarinic acetylcholine receptor medicine Receptor Acetylcholine receptor |
| Zdroj: | British Journal of Pharmacology. 153:1659-1668 |
| ISSN: | 0007-1188 |
| DOI: | 10.1038/bjp.2008.39 |
| Popis: | Background and purpose: Overactive bladder is a complex and widely prevalent condition, but little is known about its physiopathology. We have carried out morphological, biochemical and functional assays to investigate the effects of long-term nitric oxide (NO) deficiency on muscarinic receptor and β-adrenoceptor modulation leading to overactivity of rat detrusor muscle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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