| Popis: |
Biomaterials used for vascular prostheses should possess certain strength that can keep the normal blood fluidity, as well as certain flexibility and elasticity that can resist blood pulsation pressure. In order to fabricate small diameter vascular prostheses (SDVP) that possess matchable mechanical properties with natural blood vessels, a bi-layered tubular structure composed of electrospinning blended nanofiber and silk fiber was designed and prepared in this study. The inner layer of the structure, prepared through electrospinning, was composed of Poly (L-lactide-co-ε-caprolactone) (PLCL) and silk fibroin (SF) blended nanofibers. Braided silk tube was used as the outer layer of the structure. Morphological, structural and mechanical properties including peak stress, peak strain, and Youngs modulus of the prototype bi-layered SDVP were characterized initially. Results showed that the diameter range of the blended nanofiber was between 100 and 900 nm, and the fiber diameter increased with the content increase of PLCL. Through blending PLCL together with SF, peak stress and peak strain of the electrospun inner layer were improved, and that of the Youngs modulus decreased. Meanwhile, the outer layer of SDVP was stronger and had higher Youngs modulus. Those mechanical performances of the prototype bi-layered SDVP fabricated in this study are similar to natural blood vessels, which provide a promising biomaterial that could be applied on tubular tissue engineering scaffolds. |
