Antimicrobial Susceptibility Testing Performed in RPMI 1640 Reveals Azithromycin Efficacy against Carbapenem-Resistant Acinetobacter baumannii and Predicts In Vivo Outcomes in Galleria mellonella

Autor:	Sarah Miller, Kristine Goy, Rosemary She, Brad Spellberg, Brian Luna
Rok vydání:	2023
Předmět:	Pharmacology Infectious Diseases Pharmacology (medical)
Zdroj:	Antimicrobial Agents and Chemotherapy. 67
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.01320-22
Popis:	Antimicrobial susceptibility testing (AST) in RPMI 1640, a more physiologically relevant culture medium, revealed that a substantial proportion of carbapenem-resistant Acinetobacter baumannii isolates were susceptible to azithromycin, a macrolide antibiotic not currently considered effective against A. baumannii . Experiments using Galleria mellonella validated these in vitro data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db87c1dce597a4ec1f6e4e1040518fe6 https://doi.org/10.1128/aac.01320-22 Zobrazit plný text záznamu