Detection of protein kinases P38 based on reflectance spectroscopy with n-type porous silicon microcavities for diagnosing hydatidosis hydatid disease
| Autor: | Zhenhong Jia, Xiaoyi Lv, Jiajia Wang, Guo-dong Lv, Jiaqing Mo |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Silicon biology Kinase Reflectance spectroscopy p38 mitogen-activated protein kinases technology industry and agriculture chemistry.chemical_element Nanotechnology Porous silicon Photochemistry biology.organism_classification chemistry Etching (microfabrication) parasitic diseases Mesoporous material Echinococcus granulosus |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.2071332 |
| Popis: | Detection of protein kinases P38 of Echinococcus granulosus and its homologous antibody have great value for early diagnosis and treatment of hydatidosis hydatid disease. In this experiment, n-type mesoporous silicon microcavities have been successfully fabricated without KOH etching or oxidants treatment that reported in other literature. We observed the changes of the reflectivity spectrum before and after the antigen-antibody reaction by n-type mesoporous silicon microcavities. The binding of protein kinases P38 and its homologous antibody causes red shifts in the reflection spectrum of the sensor, and the red shift was proportional to the protein kinases P38 concentration with linear relationship. |
| Databáze: | OpenAIRE |
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