| Popis: |
Ferroptosis is a newly identified form of regulated cell death (RCD) in 2012, which is characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. The initiation of ferroptosis is tightly linked with numerous essential biological processes, including iron, lipid, amino acid dysregulation. The endoplasmic reticulum (ER) is a dynamic intracellular organelle, which plays an essential role in synthesis, folding, modification and transport of proteins. Under stress conditions, increased levels of unfolded or misfolded proteins within the ER lumen trigger a condition referred to as “ER stress”. The initial ER stress can protect cell for its survival, but prolonged or severe stress can lead to cell death. Recent studies reveal that ER stress is closely related to the process of ferroptosis. In cancer cells, the ferroptotic agents can induce ER stress and subsequently the ER stress pathways negatively regulate the activation of ferroptosis and result in drug resistance. However, under pathological process, ER stress promotes the activation of ferroptosis. The interconnections between ferroptosis and ER stress have become an important scientific topic in understanding the mechanisms of cell fate decision. This review summarized the regulatory networks of ferroptosis and the relationship between ferroptosis and ER stress. We expected to provide new insights and references for ferroptosis research and the therapeutic strategy of ferroptosis associated diseases. |
