Laboratory and Field Investigations of Bovine Myxovirus Parainfluenza 3 Virus and Vaccine

Autor:	L. McClelland, B. Hampil, V. V. Hamparian, L. Potash, A. Ketler, M. R. Hilleman
Rok vydání:	1961
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 87:134-138
ISSN:	1550-6606 0022-1767
Popis:	Summary A potent formalin-killed vaccine was prepared from bovine kidney cultures infected with the SF-4 strain of Myxovirus parainfluenza 3 virus. The aqueous vaccine was highly potent for guinea pigs when administered by various routes and regularly evoked the formation of neutralizing, HI and CF antibodies. On the other hand, the aqueous vaccine was of insufficient potency to immunize cattle in the dosage employed. Emulsification of the vaccine with Arlacel A-mineral oil adjuvant effected great enhancement of antigenic potency. Such material, in properdosage, evoked high level antibody response in both guinea pigs and bovines. The significance of the findings is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db630cb291681ab0bbe674dc45786e0a https://doi.org/10.4049/jimmunol.87.2.134 Zobrazit plný text záznamu