Importance of margin width in breast-conserving treatment of early breast cancer
| Autor: | Jens Overgaard, Peer Christiansen, Bent Ejlertsen, Nikolaj Amby, Anne Bodilsen, Pernille Vahl, J Michael Dixon, Birgitte Vrou Offersen, Karsten Bjerre |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
Surgical margin medicine.medical_specialty education.field_of_study Invasive carcinoma business.industry Population General Medicine Surgery 03 medical and health sciences 0302 clinical medicine Margin (machine learning) 030220 oncology & carcinogenesis Internal medicine Ipsilateral breast Cohort medicine Cumulative incidence 030212 general & internal medicine education business Early breast cancer |
| Zdroj: | Journal of Surgical Oncology. 113:609-615 |
| ISSN: | 0022-4790 |
| DOI: | 10.1002/jso.24224 |
| Popis: | Background and Method The association between margin width and ipsilateral breast tumour recurrence (IBTR, defined as invasive recurrence) was investigated in a population-based nationwide cohort of 11,900 patients undergoing breast-conserving therapy for invasive cancer. Results The median follow-up was 4.9 years. The cumulative incidence of IBTR at 5 and 9 years was 2.4% and 5.9%, respectively. A final positive margin increased the risk of IBTR (HR 2.51; 95% CI 1.02–6.23). No decrease in IBTR with a wider negative margin compared to a narrow but negative margin was observed in the adjusted analysis of margin width (>0 to 4 positive lymph nodes (P = 0.008) and re-excision (P = 0.003). A reduced risk of IBTR was observed with chemotherapy (P |
| Databáze: | OpenAIRE |
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