Large-scale genomic analyses link reproductive ageing to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Autor: Day, Felix R, McArdle, Patrick F, Johnson, Andrew D, Lunetta, Kathryn L, Yao, Jie, Keller, Margaux F, Huffman, Jennifer E, Teumer, Alexander, Thompson, Deborah J, Finucane, Hilary K, Rose, Lynda M, Nutile, Teresa, Franke, Lude L, Vuckovic, Dragana, He, Chunyan, Bulik-Sullivan, Brendan, Porcu, Eleonora, Franceschini, Nora, Zhao, Wei, Chasman, Daniel I, Pervjakova, Natalia, Altmaier, Elisabeth, Stolk, Lisette, Elks, Cathy E, Sulem, Patrick, Ruth, Katherine S, Robino, Antonietta, Smith, Jennifer A, Esko, Tõnu, Brody, Jennifer A, Schick, Ursula M, Traglia, Michela
Jazyk: angličtina
Rok vydání: 2015
DOI: 10.17615/kjjy-yd65
Popis: John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response.
Databáze: OpenAIRE