Synthesis and Regioselective Functionalization of Piperazin-2-ones Based on Phe-Gly Pseudodipeptides

Autor:	M. Teresa García-López, Ángel M. Valdivielso, Pilar Ventosa-Andrés, Marta Gutiérrez-Rodríguez, Rosario Herranz
Rok vydání:	2012
Předmět:	Stereochemistry Chemistry Organic Chemistry Surface modification Regioselectivity Reactivity (chemistry) Physical and Theoretical Chemistry Ring (chemistry)
Zdroj:	European Journal of Organic Chemistry. 2013:155-161
ISSN:	1434-193X
DOI:	10.1002/ejoc.201201221
Popis:	The synthesis of 1,4-unsubstituted piperazin-2-ones by one-pot reductive cyclization of PheΨ[CH(CN)NH]Gly pseudodipeptides is described. Studies on the reactivity of the piperazin-2-one ring showed a higher reactivity at the N4 position than at the N1 position. The stepwise regioselective functionalization of piperazin-2-one derivatives showed great potential for molecular diversity generation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db360903dcd5410720839bc861de975a https://doi.org/10.1002/ejoc.201201221 Zobrazit plný text záznamu Plný text