[99mTc]MIBI SPECT/CT for Identifying Dystonic Muscles in Patients with Primary Cervical Dystonia

Autor: Lingjing Jin, Xiaolong Zhang, Hongxing Ma, Chenghong Wang, Malam Djibo Issa, Liang Feng, Zhuoyu Zhang, Yifei Xu, Shuzhen Chen, Yougui Pan, Bing Li, Fei Teng, Junhui Su
Rok vydání: 2019
Předmět:
Zdroj: Molecular Imaging and Biology. 22:1054-1061
ISSN: 1860-2002
1536-1632
DOI: 10.1007/s11307-019-01436-0
Popis: This study aimed to evaluate the usefulness of [99mTc]sestamibi ([99mTc]MIBI) single photon emission computed tomography (SPECT)/X-ray computed tomography (CT) imaging for the identification of dystonic muscles in primary cervical dystonia (PCD) patients who underwent botulinum neurotoxin type A (BoNT-A) therapy. Thirty-six patients with PCD and 10 healthy subjects (control group) who underwent [99mTc]MIBI SPECT/CT were enrolled. The image characteristics of dystonic muscles and normal muscles were evaluated. Muscle/background ratio (MBR) of six representative muscles was calculated for dystonic muscles in PCD group and normal muscles in control group. In PCD patients, target muscles injected with BoNT-A were selected by clinical evaluations and the results of needle electromyography (EMG) were considered as the gold standard. The sensitivity, specificity, and diagnostic efficacy of SPECT/CT were obtained from the receiver operator characteristic (ROC) curve. Twenty-four PCD patients were included in our study eventually, because three PCD patients whose follow-up were lost and 9 PCD patients whose maximum reduction of Tsui scale scores was
Databáze: OpenAIRE
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