Tobramycin: Toxicological and Pharmacological Studies in Animals and Pharmacokinetic Research in Patients with Varying Degrees of Renal Impairment
| Autor: | F. G. De Rosa, R F Frongillo, U Buoncristiani, P Capitanucci |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.drug_class
business.industry Biochemistry (medical) Antibiotics Renal function Cell Biology General Medicine Urine 030204 cardiovascular system & hematology Pharmacology Biochemistry Acute toxicity Nephrotoxicity 03 medical and health sciences 0302 clinical medicine Pharmacokinetics 030220 oncology & carcinogenesis medicine Tobramycin Gentamicin business medicine.drug |
| Zdroj: | Journal of International Medical Research. 2:100-114 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/030006057400200202 |
| Popis: | Pharmacological investigations with tobramycin have been conducted in animals and in man. In the experimental animal, tobramycin showed lower acute toxicity and lower nephrotoxicity than gentamicin. Moreover, the antibiotic did not cause any significant systemic effects and was rapidly absorbed in the blood and excreted in the urine. The pharmacokinetic evaluation of tobramycin was undertaken in patients with varying degrees of reduced renal function. The influence of peritoneal and extracorporeal dialysis on the removal of the antibiotic from the serum of patients with terminal renal failure was examined. Possible tobramycin treatment schedules for patients with varying degrees of reduced renal function are briefly discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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