Antitrypanosomal activity of iridals from Iris domestica
| Autor: | Anthony L. Newsome, Jianhua Miao, Norma K. Dunlap, Anuradha Liyana Pathiranage, Jeannie Stubblefield, Xiaolei Zhou |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
biology
010405 organic chemistry Active components Chemical modification Plant Science Iris domestica Trypanosoma brucei biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry parasitic diseases Belamcanda chinensis Petroleum ether Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 18:44-50 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2016.08.025 |
| Popis: | The petroleum ether extract of Iris domestica (Belamcanda chinensis) has been evaluated for activity against Trypanosoma brucei. Bioassay-guided fractionation led to the isolation of four known iridals as the active components. Chemical modification of these isolates afforded novel stable derivatives that maintained bioactivity. This is the first known report of the antitrypanosomal activity of these compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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