Anaerobic photocleavage of supercoiled DNA by a ruthenium(II) substituted fluorinated porphyrin

Autor: Mark G. Nielsen, Shawn Swavey, Anna McCrate, Melissa Carlone
Rok vydání: 2010
Předmět:
Zdroj: Inorganic Chemistry Communications. 13:537-539
ISSN: 1387-7003
DOI: 10.1016/j.inoche.2010.01.031
Popis: Two ruthenium substituted porphyrins differing only by the substitution of a mesopentafluorophenyl group show drastically different DNA photocleavage results. The incorporation of the pentafluorophenyl group provides greater photodynamic efficiency and in addition is capable of causing DNA cleavage in the absence of oxygen.
Databáze: OpenAIRE