SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [ 14 C]SCY-078 in Albino and Pigmented Rats

Autor:	David Angulo, Stephen A. Wring, Katyna Borroto-Esoda, Eric G. Solon
Rok vydání:	2019
Předmět:	Pharmacology 0303 health sciences Kidney Lung 030306 microbiology Chemistry Spleen Urine Fungicide 03 medical and health sciences Infectious Diseases medicine.anatomical_structure medicine Distribution (pharmacology) Pharmacology (medical) Bone marrow Feces 030304 developmental biology
Zdroj:	Antimicrobial Agents and Chemotherapy. 63
ISSN:	1098-6596 0066-4804
Popis:	SCY-078, a fungicidal β-1,3-glucan synthesis inhibitor administered as intravenous or oral [ 14 C]SCY-078 to rats, was distributed primarily into tissues associated with invasive fungal disease (kidney, lung, liver, spleen, bone marrow, muscle, vaginal tissue, and skin) to levels exceeding those in plasma. Oral fraction absorbed was ∼40%. Elimination was primarily via bile and feces (∼90%) and urine (∼1.5%). Mean half-time was ∼8 h. Quantitative whole-body autoradiography showed a rapid distribution at 8 h and elimination by 168 h postdose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db1dc3469e1901573d047972552fe5c5 https://doi.org/10.1128/aac.02119-18 Zobrazit plný text záznamu