Effect of Some Sulfonamides on Renal Secretion
| Autor: | Rudolf Höber |
|---|---|
| Rok vydání: | 1942 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Kidney biology Chemistry Reabsorption Bicarbonate Sulfanilamide General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Endocrinology medicine.anatomical_structure Enzyme Biochemistry Internal medicine Carbonic anhydrase Renal physiology medicine biology.protein Secretion medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 49:87-90 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-49-13474 |
| Popis: | SummaryFollowing the addition of sulfanilamide and of sulfonamides having an unsubstituted SO2NH2 group to the Ringer-phenol red perfusion fluid of an isolated frog kidney, the reaction of the secretion turns from acid to alkali, as indicated by the color of the indicator. This effect is reversible. Reasons are proposed for the assumption that the change of reaction is due to the inhibitory action of the sulfonamides upon carbonic anhydrase and that this enzyme is involved as a catalyzer in the reabsorption of bicarbonate by the kidney. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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