Abstract 110: Age Associated Brain Volume is More Closely Correlated to Periventricular than Deep White Matter Disease
| Autor: | Paul Nyquist, Murat Bilgel, Lisa R Yanek, Taryn F Moy, Lewis C Becker, Jennifer L Cuzzocreo, David M Yousem, Jerry Prince, Diane M Becker, Brian G Kral, Dhananjay Vaidya |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Stroke. 45 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.45.suppl_1.110 |
| Popis: | Introduction: The loss of total brain volume (TBV) due to aging is associated with increasing ischemic white matter lesion volume (WMH) and dementia. Lower TBV may be secondary to chronic ischemia and hypoperfusion throughout the periventricular white matter rather than the burden of focal ischemia in the deep white matter. We hypothesized lower TBV would be more closely correlated with increasing periventricular white matter lesion volume (PV) rather than deep white matter lesion volume (DWMH). Methods: We enrolled 593 asymptomatic family members of probands with premature coronary artery disease ( Results: Participants were 58% women, 37% African-American, 29-74 years old. TBV/ICV was more correlated to PV than DWMH (correlation coefficients -0.26 and -0.11, p= Conclusions: PV is more strongly correlated to TBV than DWMH and the age associated changes in PV and TBV were more similar to one another than DWMH. The association of increasing PV with lower TBV may help to explain the association of cognitive and motor decline with increasing PV. Future longitudinal studies are needed to verify this association. |
| Databáze: | OpenAIRE |
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