Bone Regeneration in Craniofacial Reconstruction with Particulate Grafts Obtained Through Tissue Engineering

Autor:	Codruta Nicola, Simion Bran, Mihaela Hedesiu, Ondine Lucaciu, Dan Gheban, Grigore Baciut, Olga Soritau, Dorina Gui, Mihaela Baciut
Rok vydání:	2009
Předmět:	Scaffold medicine.anatomical_structure Tissue engineering Chemistry General Chemical Engineering Mesenchymal stem cell medicine Stem cell Bone regeneration Bone tissue Antler Biomedical engineering Stem cell transplantation for articular cartilage repair
Zdroj:	Particulate Science and Technology. 27:497-518
ISSN:	1548-0046 0272-6351
DOI:	10.1080/02726350903328548
Popis:	This research was developed in order to evaluate bone regeneration induced by grafts obtained through tissue engineering. Tissue engineering is an in vitro method used to obtain cell-based osteoinductive particulate bone grafts. This study evaluated the feasibility of creating engineered bone tissue using mesenchymal cells seeded on a particulate scaffold obtained from the deciduous red deer antler and the osteoconductive, osteoinductive, and osteogenetic potential of these grafts. We have chosen mesenchymal stem cells because they are easy to harvest and are capable of differentiating into cells of mesenchymal origin (osteoblasts) and producing tissue such as bone. As a scaffold we have chosen the red deer antler because it has a high level of porosity. We conducted a case control study on three groups of type CD1 mice: two study groups (n = 60) and one control group (n = 30). Bone defects were surgically induced on the left parietal bone of all subjects. In the control group we did not graft the bone de...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db0a868c750c5920aca6c60f7370e7fd https://doi.org/10.1080/02726350903328548 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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