Shearinines D–K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channels

Autor:	Ingrid Groth, Isabel Sattler, Gerhard Bringmann, Wenhan Lin, Stefan H. Heinemann, Xiang Li, Arnulf Christner, Susanne Grabley, Zhiwei Deng, Guido Gessner, Minjuan Xu, Torsten Bruhn, Corinna Lange
Rok vydání:	2007
Předmět:	Indole test Circular dichroism Strain (chemistry) biology Stereochemistry Chemistry Organic Chemistry biology.organism_classification Biochemistry Calcium-activated potassium channel Potassium channel Terpene Drug Discovery Penicillium Aegiceras corniculatum
Zdroj:	Tetrahedron. 63:435-444
ISSN:	0040-4020
DOI:	10.1016/j.tet.2006.10.050
Popis:	A chemical examination of the endophytic fungus Penicillium sp. isolated from the mangrove plant Aegiceras corniculatum resulted in the isolation and characterization of eight new indole triterpenes named shearinines D–K (1–8), along with shearinine A (9), paspalitrem A (10), and paspaline (11). Their stereostructures were determined by extensive spectroscopic data analyses and quantum chemical circular dichroism calculations. The biosynthetic relationship of all 11 alkaloids is suggested. Shearinines D (1), E (2), and (with reduced potency) G (4) exhibit significant in vitro blocking activity on large-conductance calcium-activated potassium channels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db0589d97b802dc9257477ab0d085455 https://doi.org/10.1016/j.tet.2006.10.050 Zobrazit plný text záznamu Full Text from ScienceDirect