The Influence of Simple Phenols on Collagen Type I Fibrillogenesis in vitro

Autor:	S. G. Gaidin, Yu. S. Tarahovsky, Yu. A. Kim
Rok vydání:	2018
Předmět:	0301 basic medicine 030102 biochemistry & molecular biology Hydrogen bond Chemistry Biophysics Fibrillogenesis Resorcinol Fibril 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Pyrogallol Polymer chemistry Molecule Phenols Type I collagen
Zdroj:	Biophysics. 63:162-168
ISSN:	1555-6654 0006-3509
DOI:	10.1134/s0006350918020148
Popis:	The influence of phenolic compounds with different numbers of hydroxy groups (phenol, pyrocatechol, resorcinol, and pyrogallol) on the kinetics of in vitro fibrillogenesis of collagen and on fibril structure has been studied. It has been shown that these phenols accelerate fibril formation mainly by shortening the lag phase, presumably facilitating the formation of collagen dimers and their subsequent association to linear aggregates. The accelerating activity of phenols is proportional to the number of hydroxy groups in the molecule. It increases in the series: phenol < resorcinol < pyrogallol. Therefore, the ability of phenols to accelerate fibril formation is likely to stem from the formation of hydrogen bonds with amino-acid residues in collagen chains. The hydrogen bonds may stabilize the structure of the intermediates, facilitating their interaction during fibrillogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db0095cfef2b6780ac69df4ddbc50958 https://doi.org/10.1134/s0006350918020148 Zobrazit plný text záznamu Full text from SpringerLink