| Popis: |
The prolonged action of 5α-androst-2-en-17β-ol on levator ani muscle, prostate and seminal vesicles in a single s.c. administration is evidently due to a slow metabolic transformation of its 17-hydroxy group to form an inactive 17-keto derivative. This is evidenced by the following observations: 1) There are smaller differences in biological activity between 5α-androst-2-en-17β-ol and its 17-methyl derivative than between 5α-androstan-3α,17β-diol and its corresponding 17-methyl-derivative. 2) Oxidation of 5α-androst-2-en-17β-ol with guinea pig liver dehydrogenase in vitro is, in low concentrations, slower than that of testosterone. Another probable reason for the prolonged action of 5α-androst-2-en-17β-ol is a slower resorption from subcutaneous depot. |
