An efficient and promising method to prepare Ladostigil (TV3326) via asymmetric transfer hydrogenation catalyzed by Ru–Cs-DPEN in an HCOONa–H2O–surfactant system

Autor:	Shilei Yan, Fangfei Qin, Zonghua Luo, Xingshu Li
Rok vydání:	2012
Předmět:	Inorganic Chemistry Enantiopure drug Anti alzheimer Ladostigil Chemistry Organic Chemistry Organic chemistry Surfactant system Physical and Theoretical Chemistry Transfer hydrogenation Enantiomeric excess Catalysis
Zdroj:	Tetrahedron: Asymmetry. 23:333-338
ISSN:	0957-4166
Popis:	The enantiopure multi-functional anti Alzheimer’s drug, Ladostigil (TV3326), was prepared by using asymmetric transfer hydrogenation (ATH) as a key step catalyzed by Ru–Cs-DPEN in an HCOONa–H 2 O–surfactant system. Good chemical yields with high enantiomeric excess were obtained and the catalyst could be recycled another five times.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::daecbe148d8e55564a930e96d5899778 https://doi.org/10.1016/j.tetasy.2012.02.022 Zobrazit plný text záznamu Full Text from ScienceDirect