Calixarene Methylenebisphosphonic Acids: Alkaline Phosphatase Inhibition and Docking Studies

Autor:	O. Muzychka, Valery P. Kukhar, Vsevolod Yu. Tanchuk, Andriy I. Vovk, S. O. Cherenok, V. I. Kalchenko, I. Muravyova, Alexander Shivanyuk
Rok vydání:	2008
Předmět:	Inorganic Chemistry Bovine kidney chemistry.chemical_compound Enzyme inhibition Biochemistry Docking (molecular) Chemistry Stereochemistry Organic Chemistry Calixarene Alkaline phosphatase Methylene
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 183:625-626
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426500701793311
Popis:	The inhibition of alkaline phosphatase from bovine intestine mucosa and bovine kidney by calix[4]arenes functionalized at the marcocyclic upper rim by one or two methylene bisphosphonic acid fragments have been investigated. The mechanisms of enzyme inhibition have been discussed using a molecular docking approach by computational modeling of inhibitors into active centers of E. coli alkaline phosphatase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::daec74776e5170da81ebae1d27966817 https://doi.org/10.1080/10426500701793311 Zobrazit plný text záznamu