A Practical Synthesis of l-Valyl-pyrrolidine-(2R)-boronic Acid: Efficient Recycling of the Costly Chiral Auxiliary (+)-Pinanediol

Autor:	David R. Kronenthal, Maxime Soumeillant, Frank Gibson, Michael J. Humora, Manchand Percy Sarwood, Ambarish K. Singh
Rok vydání:	2002
Předmět:	chemistry.chemical_compound Chiral auxiliary chemistry Organic Chemistry Organic chemistry Physical and Theoretical Chemistry Boronic acid Pyrrolidine
Zdroj:	Organic Process Research & Development. 6:814-816
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op025587b
Popis:	A practical synthesis of l-valyl-pyrrolidine-(2R)-boronic acid (1) is detailed. A previously disclosed synthesis of 1 (Snow, R.; Kelly, T. R.; Adams, J.; Coutts, S.; Perry, C. (Boehringer Ingelheim Pharmaceuticals, Inc.). WO 93/10127, 1993) was significantly improved by developing an efficient process for recycling the costly chiral auxiliary (+)- pinanediol.
Databáze:	OpenAIRE
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