Head and Neck Atopic Dermatitis and Malassezia-furfur-Specific IgE Antibodies

Autor:	Francisque Leynadier, C. Artigou, O. Bayrou, Antoine Flahault, C Pecquet, N. Abuaf
Rok vydání:	2005
Předmět:	medicine.medical_specialty Allergy integumentary system biology business.industry Dermatology Atopic dermatitis medicine.disease Immunoglobulin E body regions Atopy Seborrheic dermatitis Immunology medicine biology.protein Antibody business Contact dermatitis Mycosis
Zdroj:	Dermatology. 211:107-113
ISSN:	1421-9832 1018-8665
Popis:	Background: Atopic dermatitis of the head and neck (HNAD) has been recognized as a separate entity. Malassezia furfur, a lipophilic yeast, is considered to be a pathogenic allergen in this form of atopic dermatitis. Objective: The purpose of this study was to determine the level of IgE anti-M.-furfur antibodies and their relation to the severity of the disease. Methods: IgE anti-M.-furfur antibodies were assayed in 106 patients with HNAD. Controls included 25 patients with non-HNAD, 20 with nonatopic dermatitis and 16 with seborrheic dermatitis (including 4 with AIDS). Results: There was a highly significant correlation between the level of anti-M.-furfur IgE and clinical severity. Furthermore, there was a significant but smaller correlation between total IgE and clinical severity. In patients with HNAD, total IgE was higher amongst men. Conclusion: IgE anti-M.-furfur antibodies are a good and specific marker for HNAD. IgE M. furfur levels are strongly correlated with the severity of the disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dadfa52c37394c2e2beedc3b95e93254 https://doi.org/10.1159/000086438 Zobrazit plný text záznamu