ChemInform Abstract: Synthesis of the Metabolites of Clentiazem
Autor: | Mitsunori Gaino, Tsunehiro Harada, Susumu Nakamura, Kenji Matsuki, Hirozumi Inoue, Hisao Otsuka, Mikio Takeda |
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Rok vydání: | 2010 |
Předmět: | |
Zdroj: | ChemInform. 25 |
ISSN: | 0931-7597 |
Popis: | The metabolites of clentiazem in the urine or bile of rats and dogs were investigated. Fifteen basic, 6 acidic, 2 neutral and 4 conjugated metabolites were isolated. In the present paper, fourteen reference compounds as shown in Charts 1, 2 and 3 were synthesized to identify the structures of the metabolites in procedures fundamentally similar to those employed in the synthesis of the corresponding metabolites of diltiazem. |
Databáze: | OpenAIRE |
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