Plasma levels of vitamin B12, epidermal growth factor and tumor necrosis factor alpha in patients with alzheimer dementia
| Autor: | Nedret Kiliç, Melike Erol Demirbilek, Kadir Okhan Akin, Hatice Ferhan Komurcu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Plasma levels Alzheimer dementia medicine.disease Pathophysiology Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Epidermal growth factor Internal medicine medicine Dementia Tumor necrosis factor alpha Vitamin B12 business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Research in Medical Sciences. :734-738 |
| ISSN: | 2320-6071 |
| DOI: | 10.18203/2320-6012.ijrms20160509 |
| Popis: | Background: It was previously reported that vitamin B 12 (Vit B 12 ) has the regulatory effects on epidermal growth factor (EGF) and tumor necrosis factor alpha (TNF-α). The role of Vit B 12 , EGF and TNF-α in the pathogenesis of alzheimer dementia has not been elucidated yet. In this study the plasma Vit B 12 , EGF and TNF-α level were examined in individuals, between 65-99 years old with and without alzheimer dementia (AD). Methods: The study group comprised 47 patients with AD and 38 cases without dementia. EGF and TNF-α were analyzed by ELISA, and Vit B 12 was analyzed by chemiluminescence method. Results: Vit B 12 and EGF levels were significantly lower (p |
| Databáze: | OpenAIRE |
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