Modification of electrospun PVA/PAA scaffolds by cold atmospheric plasma: alignment, antibacterial activity, and biocompatibility
| Autor: | Nesrin Horzum, Alper Inan, Emine Afra Demirci, Ozan Karaman, Nehir Arik, Fatma Ibis, Utku Kürşat Ercan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Polymers and Plastics Biocompatibility Polyacrylic acid Atmospheric-pressure plasma 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Polyvinyl alcohol Electrospinning 0104 chemical sciences Nanomaterials chemistry.chemical_compound chemistry Chemical engineering Nanofiber Materials Chemistry 0210 nano-technology Antibacterial activity |
| Zdroj: | Polymer Bulletin. 76:797-812 |
| ISSN: | 1436-2449 0170-0839 |
| DOI: | 10.1007/s00289-018-2409-8 |
| Popis: | The ongoing search for better antibacterial wound care dressings has led to the design and fabrication of advanced functional nanomaterials. Taking advantage of electrospinning and cold atmospheric plasma (CAP), free-standing nanofibrous scaffolds are promising for use in novel biomedical applications. Random and aligned polyvinyl alcohol (PVA)/polyacrylic acid (PAA) nanofiber scaffolds are fabricated by electrospinning and treated with CAP. In this study, we investigate the effects of CAP treatment on alignment, hydrophilicity, antibacterial activity, and biocompatibility in determining the surface properties of the nanofibrous scaffolds. The results of vibrational polarization spectroscopy analysis indicate that CAP treatment changes the degree of alignment of the nanofibers. Furthermore, both random and aligned CAP-treated nanofibrous scaffolds show significant antibacterial activity against the E. coli strain. The results of an in vitro scratch assay reveal that CAP treatment of PVA/PAA nanofibers has no toxic effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink