TFE/Translocation Morphology Renal Cell Carcinoma

Autor:	Mariana M. Cajaiba, Nicholas G. Cost, James I. Geller
Rok vydání:	2018
Předmět:	Downregulation and upregulation Fusion transcript Chemistry Renal cell carcinoma medicine Cancer research TFEB TFE3 Chromosomal translocation Microphthalmia-associated transcription factor medicine.disease Transcription factor
Zdroj:	Rare Kidney Tumors ISBN: 9783319969886
DOI:	10.1007/978-3-319-96989-3_8
Popis:	TFE/translocation renal cell carcinoma (tRCC) was formally recognized by the WHO in 2004 as a distinct, typically translocation-associated, RCC with characteristic morphology and immunohistochemical expression of TFE3 or TFEb. Cytogenetic translocations may include TFE3-ASPS, TFE3-PRCC, TFEb-alpha, or other variants; mechanisms for TFE upregulation may be heterogenous. TFE3 and TFEB are members of the MiTF/TFE family of basic helix-loop-helix-leucine zipper transcription factors [1–3].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dac86e225fd3a40e98d64c40efe96527 https://doi.org/10.1007/978-3-319-96989-3_8 Zobrazit plný text záznamu