Green and catalyst-free synthesis of deoxyarbutin in continuous-flow
| Autor: | Xin Ye, Weike Su, Xiaoxuan Xie, Hongmiao Yao, Zhiqun Yu, Shitian Xie |
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| Rok vydání: | 2019 |
| Předmět: |
Fluid Flow and Transfer Processes
Materials science Hydroquinone 010405 organic chemistry Continuous flow Process Chemistry and Technology Side reaction 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Deoxyarbutin chemistry Chemistry (miscellaneous) Chemical Engineering (miscellaneous) Material recycling |
| Zdroj: | Reaction Chemistry & Engineering. 4:927-931 |
| ISSN: | 2058-9883 |
| Popis: | A one-step catalyst-free continuous-flow etherification protocol has been developed for the preparation of deoxyarbutin. The starting material hydroquinone was etherified with 3,4-dihydro-2H-pyran (DHP) to gain deoxyarbutin directly. A material recycling method was established to address the drawback of low per pass conversion which is caused by the reversible equilibrium of this reaction. The continuous-flow methodology is effective in inhibiting the double etherification side reaction to realize the facile and highly efficient preparation of deoxyarbutin. |
| Databáze: | OpenAIRE |
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