Monoamine oxidase A (MAOA) gene polymorphism in offenders and psychiatric patients in an Egyptian Study

Autor:	Khalda Said Amr, Nagwa Hassan Ali, El-Din Effat, Hamdy Hamed Swelim, Ahmed M. M. Galal, Laila Kamal
Rok vydání:	2014
Předmět:	Genetics medicine.medical_specialty biology Genotype frequency Polymorphism (computer science) Genotype Genetic predisposition biology.protein medicine Gene polymorphism Allele Monoamine oxidase A Psychiatry Allele frequency
Zdroj:	IOSR Journal of Pharmacy and Biological Sciences. 9:38-42
ISSN:	2278-3008 2319-7676
DOI:	10.9790/3008-09273842
Popis:	Functional characterization studies revealed that transcriptional activity of the human monoamine oxidase A (MAOA) gene is modulated by a polymorphic repetitive sequence located in 1.2 kb upstream of the ATG codon. To investigate the possible influence of the allelic variants of the MAOA gene (MAOA) on the genetic predisposition to aggressive behavior, a case-control association study of 50 psychiatric patients and 50 offenders, as well as 50 healthy controls was conducted. Statistical analysis showed no significant differences in allele or genotype frequencies between control and patient groups. Our results revealed that high significant difference was observed when comparing the 5-repeat allele frequency in psychiatric patients with control (P= 0.0001). Although there is no association between MAOA genotype and susceptibility to psychiatric disorder, and offending in the studied groups. Taken together, these findings suggest that either high or low activity alleles of the MAOA-uVNTR 30-bp polymorphism are not associated with antisocial behavior in offenders or psychiatric patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::daafec6d049b4ce9e303655fb4e77518 https://doi.org/10.9790/3008-09273842 Zobrazit plný text záznamu