Serum Leptin is Associated With Metabolic Syndrome in Obese Mexican Subjects
| Autor: | Elizabeth Aveleyra-Ojeda, Maria Fernanda Martinez-Salazar, Julio Cesar Rivera Leyva, Leticia González-Maya, Dra. Natividad Sara Concepción García Jiménez, Lourdes Rodriguez Fragoso, German Bernal Fernandez, Antonio Monroy Noyola, Angelica Meneses Acosta, Cairo David Toledano Jaimes, Sara García-Jimenez, Miguel Angel Sánchez-Aleman |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.diagnostic_test business.industry Leptin Insulin medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Public Health Environmental and Occupational Health Hematology Overweight medicine.disease Obesity Medical Laboratory Technology Insulin resistance Endocrinology Internal medicine medicine Immunology and Allergy Metabolic syndrome medicine.symptom Lipid profile business Dyslipidemia |
| Zdroj: | Journal of Clinical Laboratory Analysis. 29:5-9 |
| ISSN: | 0887-8013 |
| DOI: | 10.1002/jcla.21718 |
| Popis: | Background The metabolic syndrome (MetS) is a cluster of metabolic abnormalities including insulin resistance, dyslipidemia, high blood pressure, and abdominal adiposity. Obese patients develop leptin resistance, and an increased waist circumference (WC) due to deposition of abdominal fat. The aim of this study was to evaluate the association between circulating leptin levels and MetS among sample adult Mexican workers. Method A total of 204 workers aged 20–56 were evaluated. Anthropometric index, blood pressure, fasting plasma glucose, and lipid profile were measured by spectrophotometric methods. Fasting insulin and leptin were measured by inmunoenzimatic methods. Furthermore, homeostasis model assessment for insulin resistance (HOMA-IR) was calculated. Results The prevalence of MetS according to the ATP-III criteria was 33.8% and leptin concentrations were 2.5 times higher in women than men. Subjects with MetS had higher levels of leptin (26.7 ± 13.7) compared with those without MetS (20.1 ± 13.9; P |
| Databáze: | OpenAIRE |
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