Concise synthesis of two natural steroidal glycosides isolated from Allium schoenoprasum
| Autor: | Qingchao Liu, Wenhong Li, Dong Li, Tiantian Guo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Glycosylation
Steroidal glycosides 010405 organic chemistry Stereochemistry Combined use General Chemistry Diosgenin Carbon-13 NMR 010402 general chemistry Allium schoenoprasum 01 natural sciences Combinatorial chemistry food.food 0104 chemical sciences Human colon cancer chemistry.chemical_compound food chemistry Proton NMR |
| Zdroj: | Research on Chemical Intermediates. 42:1611-1626 |
| ISSN: | 1568-5675 0922-6168 |
| Popis: | Two natural steroidal glycosides, diosgenin 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (1) and laxogenin 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (2) with important cytotoxic activity against the HCT 116 and HT-29 human colon cancer cell lines have been efficiently synthesized via straightforward sequential glycosylation reaction with the combined use of N-phenyltrifluoroacetimidates and trichloroacetimidates donors at room temperature. All structures of the synthesized new compounds were identified by 1H NMR, 13C NMR and HRMS spectra. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink