Electrical weapons and rhabdomyolysis
Autor: | Richard M. Luceri, Mollie B. Ritter, Sebastian Kunz, Mark W. Kroll, Klaus K. Witte, John C. Criscione |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Bilirubin 01 natural sciences Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Lactate dehydrogenase medicine 030216 legal & forensic medicine biology business.industry 010401 analytical chemistry C-reactive protein Acute-phase protein Albumin General Medicine medicine.disease 0104 chemical sciences Endocrinology Myoglobin chemistry biology.protein Creatine kinase business Rhabdomyolysis |
Zdroj: | Forensic Science, Medicine and Pathology. 17:58-63 |
ISSN: | 1556-2891 1547-769X |
Popis: | It has been suggested that an application of a conducted electrical weapon (CEW) might cause muscle injury such as rhabdomyolysis and an acute inflammatory response. We explored this hypothesis by testing the effects of electrical weapons on circulating markers of inflammation and muscle damage. In a prospective study, 29 volunteers received a full-trunk 5-s TASER® X26(E) CEW exposure. Venous blood samples were taken before, 5 min after, and at 24 h following the discharge. We tested for changes in serum levels of C-reactive protein (CRP), alkaline phosphatase (ALP), myoglobin, albumin, globulin, albumin/globulin ratio, aspartate and alanine aminotransferase, creatine kinase, total protein, bilirubin, and lactic acid dehydrogenase. Uncorrected CRP and myoglobin levels were lower in the immediate post exposure period (CRP levels 1.44 ± 1.39 v 1.43 ± 1.32 mg/L; p = 0.046 and myoglobin 36.8 ± 11.9 v 36.1 ± 13.9 μg/L; p = 0.0019) but these changes were not significant after correction for multiple comparisons. There were no changes in other biomarkers. At 24 h, CRP levels had decreased by 30% to 1.01 ± 0.80 mg/L (p = 0.001 from baseline). ALP was unchanged immediately after the CEW application but was reduced by 5% from baseline (66.2 ± 16.1 to 62.7 ± 16.1 IU/L; p = 0.0003) at 24 h. No other biomarkers were different from baseline at 24 h. A full-trunk electrical weapon exposure did not lead to clinically significant changes in the acute phase protein levels or changes in measures of muscle cellular injury. We found no biomarker evidence of rhabdomyolysis. |
Databáze: | OpenAIRE |
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