Stereoselective reactions. XVII. Absolute structure-cytotoxic activity relationships of steganacin congeners and analogs

Autor:	Shigeru Tsukagoshi, Takashi Tsuruo, Kenji Koga, Tazuko Tashiro, Hidemichi Mizuguchi, Seiichi Tanida, Toyokazu Kishi, Tsuneo Ishiguro, Kiyoshi Tomioka, Nobuyasu Komeshima
Rok vydání:	1991
Předmět:	Lignan chemistry.chemical_classification biology Chemistry Stereochemistry Tetrahymena biology.organism_classification In vitro Absolute structure chemistry.chemical_compound Drug Discovery Steganacin Molecular Medicine Cytotoxic T cell Cytotoxicity Lactone
Zdroj:	Journal of Medicinal Chemistry. 34:54-57
ISSN:	1520-4804 0022-2623
DOI:	10.1021/jm00105a009
Popis:	The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the inhibitor activity of cilia regeneration in Tetrahymena were studied with regard to absolute and relative configurations. The stereochemical requirements of dibenzocyclooctadiene lignan lactones for activity were clarified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::da999305f91f7a7fa2bf69f9f50d9012 https://doi.org/10.1021/jm00105a009 Zobrazit plný text záznamu