Effects of α-Tocopherol and Its Short-Chain Analog on Metabolic Processes in Tissues of the Rabbit Visual Analyzer under Conditions of Light Stress

Autor:	N. F. Leus, S. G. Kolomiychuk
Rok vydání:	2012
Předmět:	Retina Neocortex Nicotinamide Physiology Chemistry General Neuroscience Vitamin E medicine.medical_treatment chemistry.chemical_compound medicine.anatomical_structure Biochemistry Lens (anatomy) medicine Chromane Tocopherol NAD+ kinase
Zdroj:	Neurophysiology. 44:157-162
ISSN:	1573-9007 0090-2977
DOI:	10.1007/s11062-012-9283-z
Popis:	We studied changes in the contents of nicotinamide co-enzymes (NAD, NADH, NADP, and NADPH) and of ratios of their levels in the crystalline lens, retina, and tissue of the visual neocortex, as well as in the liver and blood, of rabbits subjected to long-lasting light stress (9-h-long sessions of exposure to light of mercury-tungsten lamps, daily, for 23 weeks, spectral range 350-1150 nm, and power flux density 30 mW/cm2). Parallel injections of α-tocopherol acetate and its short-chain analog 2-4-methyl-3-pentenyl-6-acetohydroxy-2,5,7,8-tetramethyl chromane significantly compensated the light-stressinduced negative modifications of levels of reduced forms of nicotinamide co-enzymes in tissues of the rabbit visual analyzer, liver, and blood (especially ratios of NADPH/NADP levels under the action of an analog of vitamin E).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::da974af704429dc887bbd288f4afabdd https://doi.org/10.1007/s11062-012-9283-z Zobrazit plný text záznamu Plný text ve formátu PDF