Fast integrated intravascular photoacoustic/ultrasound catheter
| Autor: | Yeonsu Kang, Changhoon Choi, Seung Hoon Lee, Jinmoo Kim, Sungjo Park, Kiyuk Jang, Seunghee Cho, Hyo-Eun Park, Tae-Hoon Kim, Chulhong Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Materials science business.industry Ultrasound Photoacoustic imaging in biomedicine 02 engineering and technology 021001 nanoscience & nanotechnology medicine.disease_cause Laser 01 natural sciences Vulnerable plaque law.invention 010309 optics Catheter law 0103 physical sciences Medical imaging medicine Medical physics 0210 nano-technology business Ex vivo Intravascular imaging Biomedical engineering |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.2210790 |
| Popis: | In cardiology, a vulnerable plaque is considered to be a key subject because it is strongly related to atherosclerosis and acute myocardial infarction. Because conventional intravascular imaging devices exhibit several limitations with regard to vulnerable plaque detection, the need for an effective lipid imaging modality has been continuously suggested. Photoacoustic (PA) imaging is a medical imaging technique with a high level of ultrasound (US) resolution and strong optical contrast. In this study, we successfully developed an integrated intravascular photoacoustic/ultrasound (IV-PAUS) imaging system with a catheter diameter of 1.2 mm for lipid-rich atherosclerosis imaging. An Nd:YAG pulsed laser with an excitation wavelength of 1064 nm was utilized. IV-PAUS offers 5-mm depth penetration and axial and lateral PA imaging resolutions of 94 μm and 203 μm, respectively, as determined by imaging a 6-μm carbon fiber. We initially obtained 3-dimensional (3D) co-registered PA/US images of metal stents. Subsequently, we successfully obtained 3D coregistered PA/US ex vivo images using an iliac artery from a rabbit atherosclerosis model. Accordingly, lipid-rich plaques were sufficiently differentiated from normal tissue in the ex vivo experiment. We validated these findings histologically to confirm the lipid content. |
| Databáze: | OpenAIRE |
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